If your EBay store has only one location, in most cases you will only pay taxes on EBay sales to those shipments into your home state. You must remember, however, that when you set yourself up as a seller, you will need to contact the taxing authority to obtain the information you need for submitting taxes on sales of goods to buyers in your state of operation. Although most of your customers will probably be in a different state, there is the occasion when you will get orders from someone in the same state, and then you will need to pay taxes on EBay sales.
Of course, in those cases you are going to charge the tax to the buyer, but it is your responsibility as a seller to see that the funds are submitted to the taxing authority in your state. You also may want to check with your accountant as you set up your EBay store for more information since some states do not exempt sales to other states. Normally referred to as a “use tax,” this involves a tax on merchandise purchased in one state but used in another. Though not all states have this tax, you need to know the states that do in order to pay taxes on EBay sales when it is necessary.